AVACEN® Medical stands for Advanced VAscular Circulation ENhancement
AVACEN Medical is a noninvasive, drug-free, over-the-counter (OTC) heat therapy system indicated for: 1) temporary relief of minor muscle pain, joint pain, and stiffness 2) temporary relief of joint pain associated with arthritis, muscle spasms, and minor strains and sprains 3) muscular relaxation, and 4) temporary increase of local circulation where applied. FDA 510(k) Clearance – Indications for use
Continued research and development is being conducted for each of the topics listed below, the result of which comes in the form of articles written to help educate and inform readers of the technology.
Studies
Highlights A small randomized trial tested hand heating (with and without negative pressure) in adults with high blood sugar. The
✨ Highlights A six-week, double-blind, placebo-controlled study explored the effects of the AVACEN Treatment Method (ATM) in children with Autism
✨ Highlights A randomized, double-blind, crossover study explored whether heating one hand could influence blood glucose levels after eating. Both
Highlights: Fibromyalgia causes widespread pain, fatigue, sleep issues, and cognitive difficulties, and many people seek complementary options alongside standard care.
Background Science – Negative Pressure & Heat
Highlights Six weeks of passive heat therapy improved working memory and logical reasoning in healthy older adults. Participants completed 60-minute
Highlights 24 adults completed a single 20-minute AVACEN session. Participants reported 40% less stress, 26% less fatigue, and 25% fewer
Highlights Four weeks of heat therapy significantly reduced pain in patients with fibromyalgia. Participants also experienced improvements in physical function,
Highlights Daily superficial heat therapy significantly reduced knee osteoarthritis symptoms. Treatment improved physical function and activities of daily living. MRI
Highlights Hyperthermic baths produced significant improvements in depressive symptoms within just 2 weeks Early results were superior to those observed
Highlights Heat therapy improved walking performance in patients with peripheral artery disease (PAD) Blood pressure reductions were comparable to, or
Highlights Blood flow increased by up to +145% Significant improvements in tissue oxygenation Dynamic physiological response from pressure cycles Potential
Highlights Pain reduced by 50% after a 3-week intervention. Jaw function improved by nearly 60%. Heat therapy played a key
Highlights Vacuum therapy produced statistically significant improvements in pain and neck disability. Increased pressure pain thresholds suggest modulation of local
Highlights Warm water immersion significantly reduced pain and joint stiffness. Benefits were observed in patients with knee osteoarthritis following chronic
Case Reports
Highlights Left and right Flow Gain increased by 278% and 276%. Perfusion Index increased by 250%. A brain blood flow-related
Highlights Regional cerebral blood oxygenation increased by 144%. A cerebral blood flow-related proxy increased by 12%. A parasympathetic-related measure increased
Highlights Left and right Flow Gain increased by 265% and 224%. Perfusion Index increased by 254%. A brain blood flow-related
Highlights Regional brain oxygenation increased by 22%. Mean heart rate decreased by 8%. SDNN increased from 12 to 51 ms,
Highlights Mean heart rate decreased by 22%. SDNN, a heart rate variability measure, increased by 147%. Right-side Flow Gain increased
Highlights Regional brain oxygenation increased by 81%. A brain blood flow-related proxy increased by 202%. Two heart rate variability measures
Highlights A brain blood flow-related measure increased by 97%. A parasympathetic, or “rest-and-recover,” measure increased by 67%. Perfusion Index increased
Highlights A single 20-minute AVACEN session (left hand) was followed by a rapid increase in peripheral circulation markers, led by
Highlights: Fibromyalgia causes widespread pain, fatigue, sleep issues, and cognitive difficulties, and many people seek complementary options alongside standard care. The AVACEN Treatment Method (ATM) gently warms the microcirculation and...
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Highlights Regional brain oxygenation increased by 81%. A brain blood flow-related proxy increased by 202%. Two heart rate variability measures increased by 104% and 124%. Peripheral circulation measures also changed,...
Highlights A brain blood flow-related measure increased by 97%. A parasympathetic, or “rest-and-recover,” measure increased by 67%. Perfusion Index increased by 59%. Self-reported total wellness increased by 81%. An 80-year-old...
Highlights 24 adults completed a single 20-minute AVACEN session. Participants reported 40% less stress, 26% less fatigue, and 25% fewer aches and pains immediately afterward. Relaxation increased by 22%, energy...
Highlights Four weeks of heat therapy significantly reduced pain in patients with fibromyalgia. Participants also experienced improvements in physical function, overall disease impact, and sleep quality. Repeated heat exposure modulated...
Highlights Daily superficial heat therapy significantly reduced knee osteoarthritis symptoms. Treatment improved physical function and activities of daily living. MRI findings suggested positive effects on cartilage metabolism. The results support...
Highlights Hyperthermic baths produced significant improvements in depressive symptoms within just 2 weeks Early results were superior to those observed with a structured exercise program The intervention increased core body...
Educational Resource Notice:
This page provides research summaries and background reading for educational purposes only. It is not AVACEN labeling and is not intended to promote uses beyond AVACEN’s FDA-cleared indications. Some studies summarized here involve specific clinical populations and outcomes; these summaries do not establish that AVACEN is cleared to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult a qualified healthcare professional for medical advice.