Highlights
- A single 20-minute NanoVi® session improved key cardiometabolic markers linked to oxygen use and energy efficiency.
- Participants showed significant gains in VO₂ max, fat-burning efficiency (lower RER), and metabolic flexibility (later crossover point).
- Resting metabolism and breathing efficiency also trended upward after NanoVi® use, suggesting improved oxygen utilization even at rest.
- Fitter individuals showed the strongest response, highlighting NanoVi®’s potential to support endurance, recovery, and overall metabolic wellness.
Cardiometabolic health plays a central role in overall well-being, influencing everything from daily energy levels to long-term disease risk. Optimizing oxygen utilization and metabolic flexibility can be a game-changer for both athletes and individuals seeking to improve their health. A recent study evaluated how a single 20-minute session with the NanoVi® bio-optimization device affected key cardiometabolic markers in healthy individuals.
The research team used the PNOĒ metabolic analyzer, a clinically validated system that measures 23 biomarkers relevant to metabolic health. Ten participants of varying fitness levels underwent both resting and active cardio-metabolic assessments before and after a 20-minute NanoVi® session. Testing included an 8–10 minute resting metabolic test, a 10–12 minute metabolic test, and a 15-minute active test on a cycle ergometer, where intensity gradually increased until participants reached 8 out of 10 on the perceived exertion scale. After exercise, participants rested for 5 minutes before starting the NanoVi® session, during which they breathed normally through a nasal cannula in a relaxed, seated position.
The results were clear:
- Significant improvements in VO₂ max, resting respiratory exchange ratio (RER), and crossover point, all indicators of better fat-burning efficiency and metabolic flexibility.
- Positive, but not statistically significant, trends in resting metabolic rate (RMR) and tidal volume (VT).
- Fitter participants (higher baseline VO₂ max) showed the most pronounced benefits, possibly due to greater capillary density and oxygen absorption capacity.
The authors concluded that a single 20-minute NanoVi® session can significantly enhance fat oxidation, aerobic capacity, and metabolic efficiency, with fitter individuals responding most strongly. These results support the potential of NanoVi® therapy to improve metabolic health and justify further investigation into its applications.
This study was conducted using the NanoVi Pro® device, manufactured by Eng3 Corporation
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Figure 1. Cardiometabolic responses before and after a single 20-minute NanoVi® session.
Significant improvements were observed in VO₂ max (+7.8%), resting respiratory exchange ratio (RER; −11.0%), and heart rate crossover (+5.6%), indicating enhanced oxygen utilization, greater fat oxidation, and improved metabolic flexibility. Trends toward improvement were also seen in resting energy expenditure (+7.6%) and maximum tidal volume (VT; +5.2%), suggesting more efficient breathing and energy use. Data represent mean ± standard deviation.
Link to full paper: Read here