Highlights
- Better sleep and emotional balance. Within two weeks of daily NanoVi Exo® sessions, sleep quality improved by over 80%, and both stress and depression resolved completely, remaining stable through day 30.
- Pain relief and physical gains. Pain scores dropped by more than 50%, while physical function and social participation increased, pointing to enhanced daily comfort and activity.
- Sharper brain oxygenation and autonomic balance. Parasympathetic activity rose (+10%) as sympathetic activity declined (–9%), and brain oxygenation more than doubled (+110%), reflecting improved physiological regulation.
- Stronger mitochondrial performance. Bioenergetic tests showed dramatic improvements — mitochondrial membrane potential (+305%), network integrity (+195%), and efficiency (+12%) — suggesting more efficient cellular energy production.
Could daily 20-minute sessions with a wellness device improve sleep, reduce pain, and boost mitochondrial performance?
This case study suggests it might be possible. Over 30 days, a 60-year-old woman (“M.T.”) experienced significant physical and physiological changes after using the NanoVi Exo®.
What is the NanoVi Exo®?
The NanoVi Exo® is designed to help counteract oxidative stress and support cellular repair by delivering “activated” humidified air. This approach aims to improve recovery, balance the nervous system, and enhance overall well-being.
The Participant & Protocol
- Age: 60 years
- Routine: 20 minutes daily with the NanoVi Exo® for 30 days
- Assessments:
- Questionnaires: MOS Sleep Scale, DASS-21, PROMIS-29 at baseline, day 15, and day 30
- Physiological Measures: PPG Stress Flow and HEG (Biotekna, Italy) at baseline and day 30
- Mitochondrial Function Tests: mescreen™ bioenergetic and redox assessments
💤 Sleep Quality Improved
By the halfway point, M.T. was already sleeping better:
- Index I: ↓ 58% at day 15, reaching complete resolution by day 30
- Index II: ↓ 54% at day 15, ↓ 85% by day 30
😊 Mood & Stress Changes
- Depression: Fully resolved by day 15, maintained to day 30
- Stress: Fully resolved by day 15, maintained to day 30
- Anxiety: No change
💪 Physical Function & Social Participation
- Physical function: ↑ 19% by day 15, maintained through day 30
- Ability to participate in social roles: ↑ 15%, sustained
- Anxiety (PROMIS): ↓ 5% at day 15, ↓ 25% at day 30
⚡ Fatigue & Sleep Disturbance
- Fatigue (PROMIS): Brief rise (+22%) mid-study, then ↓ 15% by day 30
- Sleep disturbance: ↓ 24% at day 15, but ↑ 19% over baseline by day 30
💊 Pain Relief
- Pain interference: ↓ 29%
- Pain score: ↓ 43% by day 15, ↓ 57% by day 30
🧠 Autonomic & Brain Blood Flow
- Parasympathetic activity: ↑ 10%
- Sympathetic activity: ↓ 9%
- Cerebral oxygenation (rCBO₂): ↑ 110%
- Cerebral blood flow (CBF): ↓ 7%
🔋 Mitochondrial Performance Boost
- Mitochondrial membrane potential: ↑ 305%
- Mitochondrial efficiency: ↑ 12%
- Mitochondrial Index: ↑ 53%
- Network integrity: ↑ 195% (rest), ↑ 170% (stress)
- Baseline respiration: ↑ 200%
Metabolic shifts:
- Glycolytic score ↓ 62%
- Aerobic score ↓ 13%
Redox changes:
- ROS (baseline): ↑ 290%
- ROS (stress): ↑ 213%
Key Takeaways
In just one month, M.T. experienced:
- Dramatic pain relief and better physical function
- Improved sleep quality and mood stability
- Enhanced mitochondrial performance, suggesting improved cellular energy capacity
Link to full case report: Read full Case Report