Highlights
- Daily NanoVi Exo® sessions supported nervous system balance. After 30 days of 20-minute sessions, the participant showed marked reductions in stress and improved autonomic regulation, indicating a shift toward the body’s natural relaxation mode.
- Stronger parasympathetic activity. Heart rate variability metrics improved, including a 93% increase in parasympathetic activity (PNS) and a 41% reduction in sympathetic tone, showing enhanced rest-and-digest function.
- Better sleep and emotional recovery. Sleep quality improved by up to 50%, and depressive symptoms decreased by 21%, suggesting greater emotional stability and nighttime recovery.
- Consistent improvements without invasive methods. Overall, the study revealed better sleep, reduced stress, and steadier emotional health, reinforcing the potential of non-invasive, NanoVi® sessions to support well-being in older adults.
Could a daily 20-minute wellness session help rebalance the nervous system and improve sleep?
This 30-day case study of “T.J.”, a 67-year-old male, suggests the answer might be yes — with meaningful improvements in stress, sleep, and autonomic function.
What is the NanoVi Exo®?
The NanoVi Exo® uses activated humidified air to support the body’s ability to counter oxidative stress and promote recovery. By targeting cellular repair mechanisms, it may help enhance relaxation, resilience, and overall wellness.
The Participant & Protocol
- Age: 67 years
- Routine: 20 minutes daily with the NanoVi Exo® for 30 days
- Assessments:
- Questionnaires: MOS Sleep Scale, DASS-21, Chalder Fatigue Scale, PROMIS-29
- Physiological Measures: PPG Stress Flow (Biotekna, Italy)
- Measurements taken at baseline, day 15, and day 30
💤 Sleep Quality
- Index I: ↓ 50% at day 15, maintained at day 30
- Index II: ↓ 41% at day 15, ↓ 25% at day 30
😊 Mood & Stress
- Stress: ↓ 83% by day 15, maintained at day 30
- Depression: +50% at midpoint (temporary rise), then ↓ 50% from baseline by day 30
- Anxiety: No change
⚡ Fatigue
- Total fatigue: ↓ 20% at both midpoint and final
- Physical fatigue: ↓ 11% at midpoint, ↓ 33% at final
- Mental fatigue: ↓ 33% at midpoint, back to baseline by day 30
💪 Functional & Emotional Health
- Physical function: ↓ 6% at midpoint, returned to baseline by day 30
- PROMIS anxiety: ↓ 16% at midpoint, returned to baseline at final
- Depressive symptoms (PROMIS): ↓ 21% at both midpoint and final
- PROMIS fatigue: +6% at midpoint, ↓ 6% at final
- Sleep disturbance: ↓ 19% at both midpoint and final
- Social participation: ↑ 7% at midpoint, ↑ 12% at final
- Pain interference & pain score: No change
🧠 Autonomic Nervous System Balance
- Heart rate: ↓ 24%
- SDNN: ↑ 2% (overall variability)
- RMSSD: ↑ 70% (parasympathetic responsiveness)
- Total power: ↑ 3%
- Sympathetic activity (SNS LF%): ↓ 41%
- Parasympathetic activity (PNS HF%): ↑ 93% — a strong shift toward relaxation mode
Key Takeaways
After 30 days of daily NanoVi Exo® use, T.J. experienced:
- Substantial stress reduction
- Marked sleep improvement
- Significant increase in parasympathetic activity (rest-and-digest mode)
- Steadier emotional well-being with reduced depressive symptoms
While anxiety levels remained unchanged and some fluctuations occurred mid-study, the overall pattern points to improved nervous system balance and stress resilience.
Link to full case report: Read full Case Report