Highlights
- Better sleep and calmer nights. After 30 days of daily NanoVi Exo® sessions, a 75-year-old participant reported sleep quality improvements of over 60%, with deeper, more restorative rest maintained throughout the study.
- Less fatigue, more energy. Both physical and mental fatigue decreased by more than half, suggesting improved daytime vitality and recovery.
- Enhanced mood and emotional balance. Feelings of anxiety resolved completely, while stress and depression each dropped by around 50–60%, pointing to greater overall relaxation and mental ease.
- Sharper brain performance and circulation. Brain oxygenation rose by 41% and blood flow by 88%, reinforcing how daily, non-invasive sessions may support healthy neurovascular function and well-being in older adults.
Can daily sessions with a wellness device enhance sleep, reduce fatigue, and improve brain blood flow in older adults?
This 30-day case study of “G.M.”, a 75-year-old woman, suggests the answer may be yes.
What is the NanoVi Exo®?
The NanoVi Exo® delivers humidified air enriched with activated water vapor, designed to support the body’s oxidative stress recovery processes. The goal: improve wellness, promote cellular repair, and enhance resilience.
The Participant & Protocol
- Age: 75 years
- Routine: 20 minutes daily with the NanoVi Exo® for 30 days
- Assessments:
- Self-reported questionnaires: MOS Sleep Scale, DASS-21, Chalder Fatigue Scale, PROMIS-29
- Physiological measures: Hemodynamic brain metrics via HEG (Biotekna, Italy)
- Measurements taken at baseline, day 15, and day 30
💤 Sleep Quality Gains
- Index I: ↓ 50% at day 15, maintained at day 30
- Index II: ↓ 60% at day 15, ↓ 61% at day 30
😊 Mood & Stress Relief
- Depression: ↓ 60% at midpoint, ↓ 50% at final
- Stress: ↓ 60% at midpoint, ↓ 50% at final
- Anxiety: ↓ 75% at day 15, reaching 100% reduction by day 30
⚡ Fatigue Reduction
- Total fatigue: ↓ 30% at midpoint, ↓ 61% at final
- Physical fatigue: ↓ 38% at midpoint, ↓ 77% at final
- Mental fatigue: ↓ 20% at midpoint, ↓ 40% at final
💪 Functional & Emotional Well-being
- Physical function: No change
- Anxiety (PROMIS): ↓ 12% at midpoint, ↓ 36% at final
- Depressive symptoms (PROMIS): ↓ 15% at midpoint, ↓ 38% at final
- Sleep disturbance: ↓ 16% at both midpoint and final
- Social participation: ↑ 15% at midpoint, ↑ 13% at final
- Pain interference: Stable at midpoint, ↓ 2% at final
- Pain score: ↓ 25% at midpoint, ↓ 12% at final
🧠 Brain Oxygenation & Blood Flow
- Regional cerebral blood oxygenation (rCBO₂): ↑ 41%
- Cerebral blood flow (CBF): ↑ 88%
Key Takeaways
After 30 days of daily NanoVi Exo® use, G.M. experienced:
- Noticeable sleep improvements
- Significant fatigue reduction
- Complete resolution of anxiety
- Better cerebral blood flow and oxygenation
While physical function remained stable and pain changes were modest, the combined improvements in mood, sleep, and brain physiology point to promising wellness benefits.
Link to full case report: Read full Case Report