Highlights
- Daily NanoVi Exo® sessions supported relaxation and recovery. After 30 days, a 65-year-old participant showed better mood, reduced fatigue, and enhanced brain blood flow following consistent 20-minute sessions.
- Noticeable stress and anxiety relief. Stress dropped by 75%, anxiety decreased by up to 100%, and depression scores improved by the study’s end — reflecting a calmer and more balanced emotional state.
- Improved energy and nervous system balance. Fatigue levels fell by nearly 40%, and heart rate variability (HRV) metrics — including SDNN (+70%) and RMSSD (+89%) — indicated stronger parasympathetic activity and better autonomic regulation.
- Better brain oxygenation and function. Cerebral blood flow increased by 45%, and oxygenation rose by 40%, suggesting improved neurovascular efficiency and support for overall cognitive vitality.
Can a daily 20-minute wellness session support both mind and body in older adults?
This case study of “A.J.”, a 65-year-old female, suggests that consistent NanoVi Exo® use may help improve fatigue, mood, and brain oxygenation — while enhancing nervous system balance.
What is the NanoVi Exo®?
The NanoVi Exo® delivers humidified air enriched with activated water vapor designed to assist the body’s natural repair mechanisms and recovery from oxidative stress. Sessions are completely non-invasive and aim to promote relaxation, resilience, and overall vitality.
The Participant & Protocol
- Age: 65 years
- Routine: 20 minutes daily with the NanoVi Exo® for 30 days
- Assessments:
- Self-reported questionnaires: MOS Sleep Scale, DASS-21, Chalder Fatigue Scale, PROMIS-29
- Physiological measures: PPG Stress Flow & HEG (Biotekna, Italy)
- Measurements at baseline, day 15, and day 30
💤 Sleep Quality
- Index I: ↓ 50% at day 15, ↓ 17% at day 30
- Index II: ↓ 56% at midpoint, ↓ 37% at final
😊 Mood & Stress
- Stress: ↓ 75% by midpoint, maintained at day 30
- Anxiety: ↓ 100% at midpoint, ↓ 50% at final
- Depression: No change at midpoint, ↓ 100% at final
⚡ Fatigue
- Total fatigue: ↓ 13% at midpoint, ↓ 38% at final
- Physical fatigue: ↓ 20% at midpoint, ↓ 50% at final
- Mental fatigue: No change at midpoint, ↓ 17% at final
💪 Functional & Social Engagement
- Physical function: ↑ 19% at both midpoint and final
- PROMIS anxiety: Stable at midpoint, ↓ 21% at final
- Depressive symptoms (PROMIS): No change
- Fatigue (PROMIS): ↓ 31% at midpoint, ↓ 11% at final
- Sleep disturbance: ↓ 9% at midpoint, ↓ 13% at final
- Social participation: ↑ 23% at midpoint, ↑ 52% at final
- Pain interference: No change
- Pain score: ↓ 100% at midpoint, returned to baseline at final
🧠 Autonomic & Cerebral Function
- Heart rate: ↓ 2%
- SDNN: ↑ 70%
- RMSSD: ↑ 89%
- Total power: ↑ 17%
- Regional cerebral oxygenation (rCBO₂): ↑ 40%
- Cerebral blood flow (CBF): ↑ 45%
Key Takeaways
After 30 days of daily NanoVi Exo® use, A.J. experienced:
- Improved sleep quality
- Significant fatigue reduction
- Marked stress and anxiety relief
- Increased brain oxygenation and blood flow
- Strong HRV improvements, indicating enhanced parasympathetic function
While pain results were mixed, the combined physical, emotional, and physiological benefits point to the potential of NanoVi Exo® as a wellness-supportive tool for older adults.
Link to full case report: Read full Case Report