Highlights
- Transformative sleep improvement. After 30 days of daily NanoVi Exo® sessions, sleep quality scores improved by up to 90%, with complete resolution of sleep issues by the end of the study.
- Remarkable mood and stress recovery. Both depression and anxiety fully resolved within the first two weeks, while stress levels dropped 100% by day 30, showing rapid emotional relief.
- Fatigue and autonomic balance improved. Physical and mental fatigue decreased by up to 75%, alongside a strong 52% increase in parasympathetic activity and equal reduction in sympathetic tone — indicating deeper relaxation and nervous system balance.
- Enhanced brain circulation and cognitive support. Despite minor variations in oxygenation, cerebral blood flow increased by 177%, suggesting improved brain perfusion and potential support for cognitive function in older adults.
Can 20 minutes a day with a wellness device improve sleep, mood, and physiological balance?
A recent case study suggests the answer might be yes. In this 30-day exploration, an 81-year-old woman (“M.I.”) used the NanoVi Exo® device daily — and saw measurable improvements in both how she felt and in her physiological markers.
What is the NanoVi Exo®?
The NanoVi Exo® is designed to support cellular processes involved in oxidative stress recovery. Users typically breathe in humidified air that has been “activated” to help counteract oxidative damage at the molecular level, potentially aiding recovery, resilience, and overall well-being.
The Participant & Protocol
- Age: 81 years
- Routine: 20-minute NanoVi Exo® sessions every day for 30 days
- Assessments:
- Well-being questionnaires at baseline, day 15, and day 30 (MOS Sleep Scale, DASS-21, Chalder Fatigue Scale, PROMIS-29)
- Physiological measures at baseline and day 30 using PPG Stress Flow and HEG technology (Biotekna, Italy)
The Results
💤 Sleep Quality Skyrocketed
By day 15, sleep quality scores (MOS Sleep Scale) showed dramatic improvement:
- Index I: ↓ 90% by day 15, complete resolution by day 30
- Index II: ↓ 77% by day 15, ↓ 85% by day 30
😊 Mood & Stress Lifted
Measured by the DASS-21:
- Depression and anxiety resolved completely by day 15
- Stress scores dropped 67% by day 15, reaching 100% reduction by day 30
⚡ Fatigue Shifted
- Total fatigue initially rose slightly mid-study, but by day 30 had dropped 64%
- Physical fatigue ↓ 57%
- Mental fatigue ↓ 75%
💪 Functional Health Gains
From PROMIS-29 outcomes:
- Physical function ↑ 14%
- Anxiety ↓ 21%
- Sleep disturbance ↓ 37%
- Fatigue ↓ 37%
- Pain interference slightly reduced, but average pain score rose from 4.0 to 5.0
Physiological Changes
Autonomic Nervous System
- Parasympathetic activity (HF%): ↑ 52%
- Sympathetic activity (LF%): ↓ 52%
Cerebral Blood Flow
- Regional cerebral blood oxygenation (rCBO₂): ↓ 14%
- Cerebral blood flow (CBF): ↑ 177%
Key Takeaways
This case highlights notable changes after consistent NanoVi Exo® use, especially in:
- Sleep quality
- Mood and stress resilience
- Autonomic nervous system balance
- Cerebral blood flow
Although average pain score increased slightly and some measures remained unchanged (e.g., depressive symptoms on PROMIS-29), the overall trajectory was positive.
Why It Matters
For older adults, quality sleep, mood stability, and physiological balance are essential for maintaining independence and life satisfaction. While this is a single case report, the magnitude of improvement across multiple domains suggests that further research — with larger, controlled studies — is warranted.
Link to full case report: Read full Case Report