Wavelength-Specific Effects of Photobiomodulation on Mitochondrial Complexes
Highlights PBM effects on mitochondria are wavelength-, dose-, and time-dependent. Cytochrome c oxidase (Complex IV) is a primary photoreceptor for red and NIR light. Different wavelengths can stimulate or inhibit mitochondrial complexes. Both photochemical and signaling-based mechanisms are involved. Parameter optimization is essential for therapeutic efficacy. Background Mitochondrial bioenergetics play a central role in […]
Helium–Neon Laser Therapy for Segmental Vitiligo
Highlights He–Ne laser therapy induced repigmentation in patients with segmental vitiligo. Significant repigmentation occurred in approximately 60% of treated patients. Cutaneous microcirculation abnormalities improved following therapy. Sympathetic nerve function showed partial recovery. The treatment was non-invasive and well tolerated. Background Segmental vitiligo is associated with altered cutaneous microcirculation and sympathetic nervous system dysfunction. Therapeutic […]
Pulsed Transcranial Red/Near-Infrared Photobiomodulation in Veterans with Chronic TBI
Highlights Pulsed transcranial PBM improved cognitive performance in veterans with chronic TBI. Regional cerebral blood flow increased in most participants. Effects were observed even years after the original brain injury. Sequential pulsed LED stimulation was well tolerated. Findings support PBM as a promising neuromodulatory strategy in chronic TBI. Background Chronic traumatic brain injury (TBI) […]
Home-Based Photobiomodulation Shows Promise for Dementia Care
Highlights Home-based PBM improved cognition and behavior in patients with dementia. Cerebral perfusion and functional connectivity increased. The protocol combined transcranial and intranasal PBM. Treatments were well tolerated with no adverse effects. PBM may be a practical adjunct for dementia management. Background Accessible, non-invasive therapies are increasingly needed to support cognitive and behavioral function […]