Highlights
- Laser photobiomodulation (PBM) is a non-invasive therapy that modulates cellular metabolism, inflammation, and oxidative stress.
- A clinical study conducted at UNISUL (Brazil) is investigating PBM effects on the gut–brain axis.
- Treatment with the Avant Wellness LZ30 Pro Z showed reductions in abdominal circumference and inflammatory markers.
- Antioxidant defenses increased, while placebo showed no comparable benefits.
- Findings support PBM as a promising approach for metabolic and systemic inflammatory conditions.
Background and Rationale
Photobiomodulation (PBM) with LASER uses specific wavelengths of light to stimulate cellular function, reduce inflammation, and enhance tissue repair. By delivering targeted light energy, PBM promotes mitochondrial activity, leading to increased ATP production, enhanced antioxidant defenses, and modulation of inflammatory pathways. This technology has been widely studied in pain management, neurological applications, and metabolic health.
The Ongoing Study
A groundbreaking study is currently underway at the Laboratory of Experimental Neurosciences (LaNEx) at UNISUL University, Brazil, led by Dr. Daniel Martins, PT, PhD. The research focuses on the effects of PBM on the gut–brain axis using the Avant Wellness LZ30 Pro Z LASER, a high-power therapeutic device delivering:
- 1400 mW at 808 nm (near-infrared)
- 1000 mW at 637 nm (red light)
This dual-wavelength configuration was designed to optimize tissue penetration and biological response.
Key Findings
After 60 days of treatment, preliminary results demonstrated:
- Significant reduction in abdominal circumference
- Decrease in inflammatory markers (DCF)
- Increase in antioxidant enzymes, including glutathione
Importantly, these benefits were not observed in the placebo group, reinforcing the specificity of the PBM effect.
Takeaway
This study reinforces the role of high-power LASER PBM in modulating inflammation and oxidative stress through gut–brain axis mechanisms. The findings suggest promising implications for treating conditions associated with metabolic dysfunction and chronic systemic inflammation.
Reference: Data derived from ongoing experimental research conducted at the Laboratory of Experimental Neurosciences (LaNEx), UNISUL University, Brazil, using the Avant Wellness LZ30 Pro Z device.