Autonomic Nervous System Modulation Following NanoVi®: A Pilot Study
Clinical research: Susanne Neuy, MD
Institution: Praxis Dr. Neuy, Oberstaufen, Germany
Analysis and reporting: Francisco Cidral Ph.D Institution: Scientifica Consulting, Orlando Florida
Abstract
Background: The autonomic nervous system (ANS) plays a crucial role in physiological regulation by balancing sympathetic and parasympathetic activity. Heart rate variability (HRV) is a well- established method for assessing autonomic function. This pilot study aimed to evaluate the effects of NanoVi® therapy on autonomic regulation using HRV analysis.
Objective: This study explored whether a 15-minute session of NanoVi® could enhance HRV parameters, particularly those related to parasympathetic tone and stress response. Methods: Thirty-nine (n=39) participants underwent baseline HRV measurement (Group 1) followed by a 15-minute NanoVi® therapy session, after which HRV was reassessed (Group 2). HRV parameters were measured using the ANS Analysis device (Creating Health, Germany). Key autonomic markers analyzed included:
• RMSSD (Root Mean Square of Successive Differences) – a measure of parasympathetic activity.
• Stress Index (SI, Baevsky method) – an indicator of sympathetic activity.
• Alpha-1 value (DFA 1) – an index of overall autonomic regulation and coordination. Statistical Analysis: Software GraphPad Prism, v10.0 (La Jolla, CA, USA) was used for the analysis. Normality assessed with the Shapiro-Wilk test. Wilcoxon matched-pairs signed-rank test used for non-parametric comparisons.
Results : Parasympathetic Activity (RMSSD): Increased by 19.4% (14.19 to 16.95, p < 0.0001)
(Figure 1). Sympathetic Activity (Stress Index): Decreased by 45.7% (403.74 to 201.22, p < 0.0001) (Figure 2). Autonomic Regulation (Alpha-1 value): Increased by 4.5% (1.323 to 1.384, p = 0.0006) (Figure 3).
Conclusion: This pilot study suggests that a single 15-minute session of NanoVi® therapy significantly enhances parasympathetic tone, reduces sympathetic overactivity, and improves autonomic coordination. These findings indicate that NanoVi® may support autonomic balance and stress regulation, potentially benefiting individuals seeking enhanced recovery, wellness, or performance optimization. Future research with larger sample sizes, control groups, and long- term intervention studies is warranted to confirm and expand upon these results.
