Exploring the Role of Photobiomodulation in Gut Microbiota Modulation and Neuroinflammation
A new review published in Lasers in Medical Science sheds light on the potential of photobiomodulation (PBM) as a novel approach for modulating gut microbiota and addressing neuroinflammation. The study, titled “Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation”, was authored by Larissa Espindola da Silva, Daniel Fernandes Martins, and colleagues, including Francisco J. Cidral-Filho and Andrew Hewitson.
Read the full paper here: PubMed Link
Key Findings from the Review
🔹 The Gut-Brain Axis and Neuroinflammation
The gut microbiota plays a crucial role in overall health, influencing the immune system, inflammation, and brain function through the gut-brain axis. When this microbial balance is disrupted (intestinal dysbiosis), it can lead to peripheral inflammation, increased blood-brain barrier (BBB) permeability, and ultimately contribute to neuroinflammatory conditions.
🔹 Photobiomodulation’s Role in Gut Microbiota and Brain Health
PBM, formerly known as low-level laser therapy (LLLT), has been extensively studied for its anti-inflammatory, immune-modulating, and wound-healing properties. Recent studies suggest that PBM applied to the intestinal regioncan:
✔ Improve gut microbial diversity
✔ Reduce inflammatory cytokines like IL-1β, IL-6, and TNF-α
✔ Enhance mitochondrial function and ATP production
✔ Modulate immune responses, potentially alleviating neuroinflammation
🔹 Potential Applications
The authors highlight PBM’s potential in neurological and metabolic disorders influenced by the gut-brain axis, such as:
- Neurodegenerative diseases (Alzheimer’s, Parkinson’s, Multiple Sclerosis)
- Autism spectrum disorder (ASD) and mood disorders (Anxiety, Depression)
- Inflammatory bowel diseases (IBD) and metabolic syndrome
🔹 Need for Further Research
While preclinical evidence supports PBM’s effects on gut microbiota modulation, clinical trials in humans are still limited. The review emphasizes the need for standardized PBM protocols and further investigations to confirm its therapeutic efficacy.
Why This Matters
PBM presents a non-invasive and drug-free approach to addressing gut dysbiosis and its impact on brain health. Given the growing interest in integrative therapies, this review provides valuable insights into how light-based therapies might revolutionize the treatment of neuroinflammatory and gastrointestinal disorders.
For more details, read the full paper here: PubMed Link
